teknolojiarsivi.com July 16, 2018

U.S. scientists edit out disease from human embryos for first time

04 August 2017, 12:29 | Audrey Hill

Senate Confirms Christopher Wray as FBI Director

First Human Embryos Edited in US

Altering human heredity? In a first, researchers safely repaired a disease-causing gene in human embryos, targeting a heart defect best known for killing young athletes - a big step toward one day preventing a list of inherited diseases.

A team of scientists led by Shoukhrat Mitalipov at Oregon Health and Science University announced this week that they used a technology known as CRISPR to edit sections of the human genome, performing the procedure on embryonic humans.

The researchers concentrated on hypertrophic cardiomyopathy (HCM) a heart muscle disease that affects about 1 in 500 people and can result in sudden death.

But the new study, published in Nature, suggests that CRISPR might work as an aid to fertility clinic screening for risky inherited diseases, relying on a previously unknown ability of human embryos to swiftly fix their genes. The possibility of scientifically modifying humans - the object of some of the most twisted research by the Nazis - had re-surfaced after the huge strides in gene research and reproductive technology made over the last few decades. The latest research team reports it achieved "efficiency, accuracy and safety" with the approach.

Federal agencies also ban funding of research that ultimately leads to the destruction of human embryos in research.

Critics of the study were quick to allege that the research team - whose work can not be taken much further in the United States given legal limitations - had already pushed the boundaries too far.

In the study, sperm from a man who carries a mutation in the MYBPC3 gene was injected into eggs from women with healthy copies of that gene.

Despite the team's stated goal of working towards disease eradication, much of the attention around CRISPR has focused on the potential for using the technique to create so-called "designer babies" - humans with higher-than normal levels of intelligence or athletic abilities.

However, the technology was only successful on 50 percent (projected up to 74%).

Even in the 28% of embryos where CRISPR did not correct the defective sperm gene, it still erased it. In the remaining 27.6% embryos, the cellular cut-repairing mechanism introduced some unwanted insertions or deletions near the cut.

Researchers have learned to avoid patchwork embryos by editing genes during fertilization instead of after. "Moreover, if such embryos were to grow up, as will doubtless occur in the future, there are likely to be unintended effects from modifying their genes", Fr. Pacholczyk continued.

It's now illegal in the USA and many countries to implant a gene-edited embryo into a mother's womb to produce a baby. And if used universally, it could eliminate many rare genetic diseases.

None of the embryos were permitted to develop beyond five days after conception. But the prospect of editing a child's DNA before they are born remains very controversial.

Instead, the newly forming embryos made their own ideal fix without that outside help, reported Oregon Health & Science University senior researcher Shoukhrat Mitalipov.

Agus also noted that in the experiments, the technique proved to be very precise in targeting the defective gene, leaving the rest of the embryo's DNA "untouched". He and Kahn were part of a National Academy of Sciences report earlier this year that said if germline editing ever were allowed, it should be only for serious diseases with no good alternatives and done with strict oversight.

Asked about critics of genetic manipulation, he said his work has nothing to do with the creation of "designer babies" through genetic manipulation to give the children traits desired by the parents.

Other News

Trending Now

Geoffrey Kondogbia scores outrageous own goal against Chelsea, fans can't believe it
Here, we take a look at the talking points from the game - including the outrageous own goal Geoffrey Kondogbia scored for Chelsea ...

US Navy ship fires warnings at Iranian ship
Last month, a Navy Fifth Fleet spokesman, Commander Bill Urban, told Newsweek that an Iranian vessel trained a laser on a U.S. The Iranian vessel did not respond when bridge-to-bridge communication was initiated by the US crew, the official said.

Donald Trump has a new chief of staff: Who is John Kelly?
In a written statement, Priebus said it has been one of the greatest honours of his life to serve the President and the country. Spicer had adamantly opposed bringing on the NY financier and former Trump campaign fundraiser, multiple sources said.

Audi Sticks With Diesel While Rest of VW Drives Hard for Electrics
If EU officials ultimately find that the carmakers broke competition law, they could fine them billions of euros. BMW has hit back at suggestions it colluded with other European manufacturers on diesel emissions .

Guardiola insists Man City aren't finished in defender chase
Iheanacho is on the verge of joining th Foxes, after dropping down the pecking order in Guardiola's attacking options. I have an idea, and after I go to the training sessions and I have a look, I watch my players.

'Kashmir is India and India is Kashmir', says Rahul Gandhi
However, his party's coalition partner has condemned Dr Abdullah's statement. "Talk about spinning a statement". He said Abdullah must tell "his friends" in Pakistan to stop exporting terror and meddling in Kashmir.

Teen jumps from plane onto SFO tarmac
The American Airlines flight 5242 was preparing for takeoff from the terminal at Charlotte Douglas International Airport. The teen, who appeared to be in emotional distress during the flight, was not injured, Yakel said.

Israel says Jerusalem mosque metal detectors to stay, may be reduced
Angry demonstrations calling for the removal of the metal detectors are also taking place in cities across the Muslim world. The Palestinian president has suspended all contacts with Israel until metal detectors near the al Aqsa mosque are removed.

Toyota reportedly set to release fast-charging, long-range electric cars by 2022
Electric cars have made resounding progress in recent years, but they have yet to break into the mainstream market. According to the Japanese newspaper, the new electric vehicle will be launched at first in Japan in 2022.

Anti-Putin Financier: Trump Dossier Firm Was Acting On Behalf Of Russia
And that's the one thing we can conclude with certainty about what happened in that meeting, ' Browder testified . Trump's stunning election victory over Democrat Hillary Clinton .