teknolojiarsivi.com May 26, 2018

Researchers ideal an artificial womb that works as well as ewe do

03 May 2017, 12:39 | Audrey Hill

Researchers ideal an artificial womb that works as well as ewe do

Premature lambs kept alive in 'plastic bag' womb

"We've been extremely successful in replacing the conditions in the womb in our lamb model", said Alan Flake, who's a fetal surgeon at Children's Hospital of Philadelphia who led the study published in the journal Nature Communications.

The foetal lambs grew in a temperature-controlled, near- sterile environment, breathing amniotic fluid as they normally would do in the womb, their hearts pumping blood through their umbilical cord into a gas exchange machine outside the bag.

Premature infants weighing as little as a pound are hooked to ventilators and other machines inside incubators, so their lungs can more fully develop.

The plastic "biobag" womb is filled with filled with an electrolyte solution which acts like amniotic fluid in the uterus.

In early-stage testing, conducted on lambs, they found that extremely premature lambs grew apparently regularly, inside of the container for about three to four weeks.

Although the technology has only been tested on sheep, researchers hope it could become a lifesaver for many premature human babies in just a few years.

The eight fetal lambs who were tested in the device showed normal development.

"They appear to have normal development in all respects", said Dr Flake as one of the survivors reached a year old.

The whole system is created to closely mimic nature and buy the tiniest newborns a few weeks to develop their lungs and other organs. Those that do survive are at a 90% risk of morbidity and severe illnesses such as lung disease, cerebral palsy and complications caused by underdeveloped organs. The environment of each artificial womb allowed all of the lamb fetuses to survive and thrive.

Dena Davis, a bioethicist at Lehigh University, doesn't like the idea of using the artificial wombs on humans at all. It was developed at the Children's Hospital of Philadelphia (CHOP) for the much more admirable objective of keeping premature babies alive and healthy.

The device is simpler than previous attempts at creating an artificial womb, which have not yet panned out.

The age of the lambs and lung development phases equated to 22- to 24-week-old human infants. One of the surviving lambs now lives a healthy life on a farm in Pennsylvania. The team is talking to the F-D-A, in hopes of starting human trials in a year or two.

Flake stressed that the womb-like system is not meant to support premies any younger than today's limits of viability - not what he calls the more "sensationalistic" idea of artificially growing embryos. It could also reduce the estimated $43 billion hospitals spend on premature infant care annually.

Other News

Trending Now

NFL prospect denies rape report made to police; no charges
Police gathered information from Conley's accuser - a 23-year-old woman - at the hotel early that morning. Former Ohio State corner Gareon Conley is a suspect in an ongoing sexual assault investigation.

Shattenkirk nets OT winner for Caps; Crosby exits
Afterward, Penguins coach Mike Sullivan deferred any update on his injury players' health to Tuesday pending overnight evaluation. He was kicked out of the game for the hit as he should have been, but should the league office really take it to this guy.

Trade Ministry issues concentrate export permit for Freeport
Also, Director Jon C/ Madonna sold 14,000 shares of the firm's stock in a transaction that occurred on Wednesday, February 1st. Regal Investment Advisors LLC increased its position in shares of Freeport-McMoRan by 1.3% in the third quarter.

Storms Leave Trail of Destruction in Arkansas, Oklahoma and Texas
In Arkansas, the search continued for two children separated from their mother after their vehicle was swept away by flood waters. People are taking stock of the damage after severe weather over the weekend killed at least 14 people in five Southern states.

Prominent firm to defend 'Bachelor' star in Iowa crash case
Chris ended up fleeing the scene of the accident and was arrested soon after, but is already out on a $10,000 bond. He "would not come out", the attorney said, until officials obtained a search warrant, which "took hours".

BlackBerry KeyOne now available in the United Kingdom , exclusively from Selfridges
The phone will also sell in the United States with TCL gearing up to sell unlocked CDMA and GSM versions. Besides the U.S. and Canada, the KEYone is also expected to launch in other key markets soon.

Homers by Mancini, Schoop carry Orioles past Red Sox 4-2
Rather than thank Barnes for having his back by throwing at Machado, Pedroia immediately got Machado's attention from the dugout. OF Joey Rickard (sprained finger) took soft-toss swings in a session manager Buck Showalter called "very encouraging".

Target's Mario Kart Makeover Is Facing Backlash for the Weirdest Reason
Similar to Gamecube's excellent Mario Kart: Double Dash , you'll be able to hold onto 2 items at a time in this iteration of Kart. As you can see in the screenshot to the right, Nintendo will be introducing what they're calling a "mega event" to the game .

BOJ keeps monetary policy unchanged, says 2020 Games to help
The latest set of February inflation figures from Japan have exhibited little signs of taking off. However, the BoJ cut its inflation growth forecast to 1.4% from 1.5% for the same period.

Australian Olympic staffer steps down pending investigation
Next week, International Olympic Committee vice president Coates faces the first challenge to his 27-year reign as AOC president. It followed accusations of bullying and threatening behavior made by former CEO Fiona de Jong and other employees.